CLINICAL SIGNIFICANCE OF MDR1 GENE POLYMORPHISMS
Keywords:
pharmacogenetics, P - glycoprotein, MDR-1 genes, chronic gastritis, individual pharmacotherapyAbstract
The article notes that the individualization of medicine is an innovative direction that increases the safety and effectiveness of pharmacotherapy, a modern methodology for the modernization of the healthcare system. The novelty of this study is that for the first time the activity and influence of allelic variants of the MDR-1 gene on the pharmacodynamics and efficacy of drugs used for the treatment of chronic gastritis and the development of methods of a differentiated approach to the treatment of this pathology will be studied. Knowing the effect of the encoded MDR-1 gene on the pharmacokinetics of the drug P-glycoprotein, the appointment of the drug increases the effectiveness and safety of pharmacotherapy, thereby increasing its medical, economic and social significance.
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