FEATURES OF CYP2C19 GENE FOR INDIVIDUALIZED PHARMACOTHERAPY

Authors

  • Ochilov Alisher Kamilovich (PhD) E-mail: alimed@inbox.ru Department of Pharmacology and clinical pharmacology, Bukhara state medical institute Abu Ali ibn Sino, Bukhara, republic of Uzbekistan; Author

Keywords:

Cytochrome p450, gene polymorphism, CYP2С19 genes, chronic gastritis, individual pharmacotherapy.

Abstract

The article notes that pharmacotherapy taking into account the patient’s genotype is a young area that contributes to the safety and effectiveness of treatment with proton pump inhibitors. The determination of CYP2C19 gene polymorphism allows one to initially determine the tactics of treatment with proton pump inhibitors in patients with acid-dependent diseases.

References

Arvanitidis, K. Genetic polymorphisms of drug-metabolizing enzymes CYP2D6, CYP2C9, CYP2C19 and CYP3A5 in the Greek population // К. Arvanitidis, G. Ragia, M. Iordanidou et al.//Fundam. Clin. Pharmacol. 2007. Vol. 21 №4. P. 419 - 426.

Sara Vélez Gómez, Isaura Torres, Rubén Darío Manrique, Mauricio Duque, Juan Esteban Gallo // Aplicación farmacogenómica de los genes CYP2C19, CYP2C9 y VKORC1 implicados en el metabolismo de los fármacos clopidogrel y warfarina. Revista Colombiana de Cardiología. Volume 25. Issue 6. 2018. Pages 396-404.

Мiguel A. López-García, Iris A. Feria-Romero, Héctor Serrano, Darío Rayo-Mares, Pietro Fagiolino, Marta Vázquez, Consuelo Escamilla-Núñez, Israel Grijalva, David Escalante-Santiago, Sandra Orozco-Suarez // Influence of genetic variants of CYP2D6, CYP2C9, CYP2C19 and CYP3A4 on antiepileptic drug metabolism in pediatric patients with refractory epilepsy. Pharmacological Reports. Volume 69. Issue 3. 2017. Pages 504-511.

Efrén Martínez-Quintana, Fayna Rodríguez-González, José María Medina-Gil, Paloma Garay-Sánchez, Antonio Tugores // Actividad de CYP2C19 y factores de riesgo cardiovascular en pacientes con síndrome coronario agudo. Medicina Clínica. Volume 149. Issue 6. 2017. Pages 235-239.

Ochilov A.K., G.S. Ochilova. "Surunkali gastrit uchun farmakoterapiyada CYP2C19 genining ahamiyati" Biologiya va tibbiyot muammolari, 2019, № 4 (113)

Ochilov A.K., Musayeva D.M." CYP2C19 genining allel variantlariga qarab surunkali gastritni davolash "xalqaro ilmiy - amaliy onlayn - konferensiya" XXI asrda tibbiyot fanining dolzarb masalalari " Toshkent shahri, 25.04.2019 y.

Ochilov A.K., Ochilova G.S. CYP2C19 gen polimorfizmlarining klinik ahamiyati // Universitet fani: kelajakka qarash. Kursk davlat tibbiyot universitetining 85 yilligiga bag'ishlangan xalqaro ilmiy konferensiya materiallari bo'yicha ilmiy ishlar to'plami (2020 yil 7 fevral) I jild. 376379 S.

Ochilov A.K., Ochilova G.S.The Significance of Polymorphism of Genes Involved in the Stages of Pharmacokinetics of Drugs Used for the Treatment of Peptic Ulcer Disease//American Journal of Science and Learning for Development ISSN 2835-2157 Volume 2 | No 1 | January -2023

Ochilova G.S., Ochilov A.K. Modern Approaches to the Treatment of Chronic Gastritis: Achievements and Prospects//American Journal of Science and Learning for Development ISSN 2835-2157 Volume 2 | No 1 | January -2023

Ochilova G. S. Helicobacter PYLORI genetik xususiyatlarining ovqat hazm qilish tizimi kasalliklari patogenezidagi roli // ta'lim yangiliklari: XXI asrda o'tkazilgan tadqiqot № 7 (100) 2023 yil fevral 1-qism.

Downloads

Published

21-11-2023

How to Cite

Ochilov Alisher Kamilovich (PhD). (2023). FEATURES OF CYP2C19 GENE FOR INDIVIDUALIZED PHARMACOTHERAPY. Oriental Journal of Academic and Multidisciplinary Research , 1(2), 49-54. https://inno-world.uz/index.php/ojamr/article/view/39